Facile Synthesis of Methyl 2-Formyl-5-hydroxymethyl-3-furancarboxylate

AÁS Toró, P Deslongchamps

Index: Toro, Andras; Deslongchamps, Pierre Synthetic Communications, 1999 , vol. 29, # 13 p. 2317 - 2321

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Abstract

Abstract A short practical synthesis of the title trisubstituted furan is presented. It involves a high yield Knoevenagel condensation of glyceraldehyde and methyl acetoacetate to the furan nucleus and, following a protection of the furyl alcohol, a radical bromination then a Kröhnke reaction of the furyl bromide intermediate.