Photolytic control of peptide self-assembly

CJ Bosques, B Imperiali

Index: Bosques, Carlos J.; Imperiali, Barbara Journal of the American Chemical Society, 2003 , vol. 125, # 25 p. 7530 - 7531

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Citation Number: 65

Abstract

Herein, we present a methodology that allows for the temporal control of fibrillization of amyloidogenic peptides. This general approach implements a photolabile linker that connects the amyloidogenic peptide to a fibril-inhibitory unit, in this case, a pentamer of amino acids modified with the solubilizing N, N-dimethylethylenediamine (DMDA) units. Upon photolysis, the linker can be dissociated to afford the intact and native ...