Process development toward the pilot scale synthesis of the piperidine-based cocaine analogue and potent dopamine and norepinephrine reuptake inhibitor CTDP …

…, MD Ironside, GS Knox, F Mohammadi

Index: Mobele, Bingidimi I.; Kinahan, Taryn; Ulysse, Luckner G.; Gagnier, Steven V.; Ironside, Michael D.; Knox, Graham S.; Mohammadi, Farahnaz Organic Process Research and Development, 2006 , vol. 10, # 5 p. 914 - 920

Full Text: HTML

Citation Number: 6

Abstract

(+)-Methyl 4β-(4-chlorophenyl)-1-methylpiperidine-3α-carboxylate hydrochloride (CTDP 31,446) is known as a dopamine reuptake inhibitor. This cocaine analogue lacking the tropane skeleton is being considered for potential treatment of cocaine addiction. Herein we report the development of a scalable process for the preparation of this compound. This study was mainly aimed at improving the process throughput, eliminating ...