High-Throughput Chemical Modification of Oligonucleotides for Systematic Structure–Activity Relationship Evaluation

…, SS Nerurkar, DM Tellers, WM Flanagan…

Index: Peacock, Hayden; Fucini, Raymond V.; Jayalath, Prasanna; Ibarra-Soza, Jose M.; Haringsma, Henry J.; Flanagan, W. Michael; Willingham, Aarron; Beal, Peter A. Journal of the American Chemical Society, 2011 , vol. 133, # 24 p. 9200 - 9203

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Abstract

Chemical modification of siRNA is achieved in a high-throughput manner (96-well plate format) by copper catalyzed azide–alkyne cycloadditions. This transformation can be performed in one synthetic operation at up to four positions with complete specificity, good

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