Tetrahedron

Ozonation of thionucleosides. A new chemical transformation of 4-thiouracil and 6-thioguanine nucleosides to cytosine and adenosine counterparts

R Saladino, C Crestini, F Occhionero, R Nicoletti

Index: Saladino, Raffaele; Crestini, Claudia; Occhionero, Francesca; Nicoletti, Rosario Tetrahedron, 1995 , vol. 51, # 12 p. 3607 - 3616

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Citation Number: 17

Abstract

The ozonation of 4-thiopyrimidine and 6-thiopurine nucleosides in presence of amines afforded selectively and under mild experimental conditions several cytidine and adenosine nucleosides. The same reaction carried out in presence of alcohols afforded O4-or O6- alkylated derivatives of the nucleosides.

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