A CONVENIENT SYNTHESIS OF METHYL 4-AMINO-5-CHLORO-2-MTHOXYBENZOATE
RL Ehrenkaufer, JG Scripko…
Index: Ehrenkaufer, Richard L.; Scripko, James G.; Hoffman, Patricia L. Organic Preparations and Procedures International, 1992 , vol. 24, # 1 p. 64 - 66
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Abstract
A common feature of many neuroleptic drugs available on the market today is the 4-amino-5- chloro-2-methoxybenzoic acid moiety.* V2 During a program of synthesizing a number of these drugs and their radiolabelled analogues for evaluation as potential Positron Emission Tomography imaging agents, we needed to develop a convenient synthesis of the parent acid. Published syntheses involved protectiondeprotection of the nitrogen? to prevent ...
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