Tetrahedron letters

Synthesis and lyotropic phase behavior of novel nonionic surfactants for the crystallization of integral membrane proteins

J Walton, GJT Tiddy, SJ Webb

Index: Walton, Jeffrey; Tiddy, Gordon J. T.; Webb, Simon J. Tetrahedron Letters, 2006 , vol. 47, # 5 p. 737 - 741

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Abstract

A series of new sugar-based nonionic surfactants have been synthesized and their lyotropic liquid crystalline properties characterized. When in contact with water, these surfactants formed a range of lyotropic liquid crystalline phases, including cubic, hexagonal, and lamellar, as well as a separate micellar phase. These are features that have promise for the crystallization of integral membrane proteins.