An efficient one-pot protocol for regioselective synthesis of 3-aryl-6, 8-dialkyl-7-thioxo-7, 8-dihydropyrimido [4, 5-c] pyridazine-5 (6 H)-ones

J Khalafy, M Rimaz, H Rabiei…

Index: Khalafy, Jabbar; Rimaz, Mehdi; Rabiei, Hossein; Panahi, Leila Journal of Sulfur Chemistry, 2013 , vol. 34, # 4 p. 395 - 406

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Citation Number: 3

Abstract

A series of 3-aryl-6, 8-dialkyl-7-thioxo-7, 8-dihydropyrimido [4, 5-c] pyridazine-5 (6 H)-one derivatives have been regioselectively synthesized via the one-pot three-component reaction of 1, 3-dimethylthiobarbituric acid and 1, 3-diethylthiobarbituric acid with various arylglyoxals in the presence of hydrazinium dihydrochloride in warm ethanol. These new substituted pyrimidopyridazines may be potential monoamine oxidase inhibitors.