Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias
HDH Showalter, JL Johnson, JM Hoftiezer…
Index: Showalter; Johnson; Hoftiezer; Turner; Werbel; Leopold; Shillis; Jackson; Elslager Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 121 - 131
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Citation Number: 101
Abstract
Chromophore modification of the anthracenediones related to mitoxantrone (5) in an attempt to provide agents with diminished or no cardiotoxicity has resulted in a novel class of DNA binders, the anthrapyrazoles (9). Their synthesis was carried out by a two-stage condensation sequence starting from requisite 1, 4-or 1, 5-dichloro-9, 10-anthracenedione precursors. Reaction with a monoalkylhydrazine gave a chloroanthrapyrazole ...
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[Beylin; Colbry; Goel; Haky; Johnson; Kanter; Leeds; Leja; Lewis; Rithner; Showalter; Sercel; Turner; Uhlendorf Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 1 p. 85 - 96]
[Beylin; Colbry; Goel; Haky; Johnson; Kanter; Leeds; Leja; Lewis; Rithner; Showalter; Sercel; Turner; Uhlendorf Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 1 p. 85 - 96]