Analgesic activity of novel spiro heterocycles. 2-Amino-7-oxa-3-thia-1-azaspiro [5.5] undec-1-enes and related compounds

N Cohen, BL Banner, RJ Lopresti…

Index: Cohen,N. et al. Journal of Medicinal Chemistry, 1978 , vol. 21, p. 895 - 900

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Citation Number: 15

Abstract

certain of these compounds revealed significant analgesic activity, a discovery which encouraged us to prepare a variety of derivatives and analogues. 2 A major goal of this program was to determine which structural features or combinations thereof in these unusual molecules were required for the observed pharmacological a~ tivity.~ In this report, we wish to present preliminary analgesic testing data obtained for several of the original ...