Sugar??Based Synthesis of Tamiflu and Its Inhibitory Effects on Cell Secretion

…, S Ng, J Zhang, J Zeng, A Than, P Chen…

Index: Ma, Jimei; Zhao, Yanying; Ng, Simon; Zhang, Jing; Zeng, Jing; Than, Aung; Chen, Peng; Liu, Xue-Wei Chemistry - A European Journal, 2010 , vol. 16, # 15 p. 4533 - 4540

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Citation Number: 31

Abstract

Abstract Tamiflu is currently the most effective drug for the treatment of influenza, but the insufficient supply and side-effects of this drug demand urgent solutions. We present a practical synthesis of Tamiflu by using novel synthetic routes, cheap reagents, and the abundantly available starting material D-glucal. The strategy features a Claisen rearrangement of hexose to obtain the cyclohexene backbone and introduction of diamino ...