The use of palladium chloride as a precatalyst for the amination of aryl bromides

XX Zhang, MC Harris, JP Sadighi…

Index: Zhang, Xiao-Xiang; Harris, Michele C.; Sadighi, Joseph P.; Buchwald, Stephen L. Canadian Journal of Chemistry, 2001 , vol. 79, # 11 p. 1799 - 1805

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Citation Number: 16

Abstract

The use of palladium chloride as a precatalyst for the amination of aryl bromides is reported. To overcome the poor solubility of palladium chloride in commonly used solvents, a procedure was developed in which PdCl2 was preheated with neat amine in the presence of a phosphine ligand before the addition of the other reaction components. This protocol is effective for a broad range of substrate combinations using several types of phosphine ...

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