Journal of Heterocyclic Chemistry

An inexpensive, selective procedure for oxidizing α??methyl to α??formyl pyrroles pavel bobal

DA Lightner

Index: Bobal; Lightner Journal of Heterocyclic Chemistry, 2001 , vol. 38, # 5 p. 1219 - 1221

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Abstract

Abstract α-Methylpyrroles are converted to α-formyl by sodium bromate in aqueous methanol in∼ 60% yield. Adding 1% ceric ammonium nitrate as a co-oxidant brings the isolated yields of synthetically useful 2-formylpyrroles 2a-d up to∼ 70%, or close to those found when using only the considerably more expensive ceric ammonium nitrate as oxidant.