Noncovalent inhibition of the serine proteases, α-chymotrypsin and trypsin by trifluoro (organo) borates

R Smoum, A Rubinstein, M Srebnik

Index: Smoum, Reem; Rubinstein, Abraham; Srebnik, Morris Organic and Biomolecular Chemistry, 2005 , vol. 3, # 5 p. 941 - 944

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Citation Number: 22

Abstract

A series of potassium organotrifluoroborates were synthesized. Their stability to hydrolysis was determined in D2O, TRIS and phosphate buffer. It was found that in both D2O and TRIS buffers, these compounds are quite stable, whereas in phosphate buffer rapid hydrolysis occurs. Based on these results, a study was undertaken to determine whether potassium organotrifluoroborates can serve as protease inhibitors. It was found that potassium ...