The mechanism of formation of 6-Aryl-4, 6-dioxohexanoic acids from arylketones and succinic anhydride

WV Murray, P Lalan, PJ Connolly

Index: Murray, William V.; Lalan, Praful; Connolly, Peter J. Tetrahedron Letters, 1993 , vol. 34, # 33 p. 5189 - 5192

Full Text: HTML

Citation Number: 2

Abstract

Abstract Compounds 2a-d could be synthesized directly from the requisite acetophenone enolate and succinic anhydride. Intermediate O-acylated products 1a-d were observed. Compounds 1a-d could be converted to 2a-d by treatment with at least two additional equivalents of the acetophenone enolate. Evidence indicates that 1 is an intermediate in the synthesis of 2 and that the direct reaction requires at least two equivalents of ...