Bisubstrate reaction templates. Examination of the consequences of identical versus different binding sites

TR Kelly, GJ Bridger, C Zhao

Index: Ross Kelly; Bridger, Gary J.; Zhao, Chen Journal of the American Chemical Society, 1990 , vol. 112, # 22 p. 8024 - 8034

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Citation Number: 140

Abstract

Abstract: A reaction template (1~ 9) possessing two binding sites is described. The template was designed to use hydrogen bonding to simultaneously (but transiently) bind two substrates, giving rise to a ternary complex (2= 12), which positions the substrates in an orientation that facilitates reaction between them. Bisubstrate reaction template 9 was synthesized and shown to accelerate the reaction between substrata 10 and 11. Control ...