Tetrahedron

The application of Stille cross-coupling reactions with multiple nitrogen containing heterocycles

R Selig, D Schollmeyer, W Albrecht, S Laufer

Index: Selig, Roland; Schollmeyer, Dieter; Albrecht, Wolfgang; Laufer, Stefan Tetrahedron, 2011 , vol. 67, # 47 p. 9204 - 9213

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Citation Number: 5

Abstract

Substituted imidazoles and purine bioisosteres have been widely studied in the literature. We endeavored to combine these heterocyclic core structures into precursors, especially 7- azaindoles, of previously unknown pharmacologically relevant lead structures. A highly flexible synthetic procedure was developed, derived from investigations of the influence of the substrates, solvents, ligand systems, and side reactions.

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