Organic letters

Switching the chemoselectivity in the amination of 4-chloroquinazolines with aminopyrazoles

Z Shen, Y Hong, X He, W Mo, B Hu, N Sun, X Hu

Index: Shen, Zhenlu; Hong, Yiming; He, Xiaofei; Mo, Weimin; Hu, Baoxiang; Sun, Nan; Hu, Xinquan Organic Letters, 2010 , vol. 12, # 3 p. 552 - 555

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Citation Number: 19

Abstract

The chemoselectivity in the amination of 4-chloroquinazolines with 3-amino-1 H-pyrazoles was studied. Under the conditions of Pd2 (dba) 3/Xantphos/Na2CO3, 4-chloroquinazolines underwent selective amination with the cyclic secondary amino group of 3-amino-1 H- ...