Low Temperature Studies of Iron??Catalyzed Cross??Coupling of Alkyl Grignard Reagents with Aryl Electrophiles

…, PF Larsson, P Emamy, A Hedström…

Index: Kleimark, Jonatan; Larsson, Per-Fredrik; Emamy, Parisa; Hedstroem, Anna; Norrby, Per-Ola Advanced Synthesis and Catalysis, 2012 , vol. 354, # 2-3 p. 448 - 456

Full Text: HTML

Citation Number: 19

Abstract

Abstract The title reaction has been studied under low temperature conditions. Coupling with active substrates can be done even at dry ice temperature. Initial rate studies at− 25 C indicate that high concentrations of any reagent can lead to either complete or partial catalyst deactivation. Under strongly reducing conditions, iron seems to form less active complexes that only slowly re-enter the catalytic cycle, possibly through bimolecular ...

Related Articles:

Photocatalyzed [2+ 2+ 2]-cycloaddition of nitriles with acetylene: an effective method for the synthesis of 2-pyridines under mild conditions

[Heller, Barbara; Sundermann, Bernd; Buschmann, Helmut; Drexler, Hans-Joachim; You, Jingsong; Holzgrabe, Ulrike; Heller, Eberhard; Oehme, Guenther Journal of Organic Chemistry, 2002 , vol. 67, # 13 p. 4414 - 4422]

Tetraphosphine/palladium catalysed Suzuki cross-coupling reactions of aryl halides with alkylboronic acids

[Kondolff, Isabelle; Doucet, Henri; Santelli, Maurice Tetrahedron, 2004 , vol. 60, # 17 p. 3813 - 3818]

A convenient method for the regioselective synthesis of 4-alkyl (aryl) pyridines using pyridinium salts.

[Akiba, Kin-ya; Iseki, Yuji; Wada, Makoto Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 7 p. 1994 - 1999]

More Articles...