Synthesis and structure-activity relationship of new cephalosporins with amino heterocycles at C-7. Dependence of the antibacterial spectrum and. beta.-lactamase …

F Jung, C Delvare, D Boucherot, A Hamon…

Index: Jung; Delvare; Boucherot; Hamon; Ackerley; Betts Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1110 - 1116

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Citation Number: 21

Abstract

Cephalosporins with new aminobenzimidazole and aminoimidazoline heterocycles at C-7 have been synthesized starting with versatile C-7 isocyanide dihalide synthons. The aminobenzimidazoles have a broad spectrum of antibacterial activity, including Gram- positive and Gram-negative organisms, but possess limited P-lactamase stability. In contrast, the aminoimidazolines have a narrow spectrum of antibacterial activity, limited to Gram- ...

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