(E)-Selective Horner–Wadsworth–Emmons reaction of aryl alkyl ketones with bis (2, 2, 2-trifluoroethyl) phosphonoacetic acid

S Sano, Y Takemoto, Y Nagao

Index: Sano, Shigeki; Takemoto, Yuka; Nagao, Yoshimitsu Tetrahedron Letters, 2003 , vol. 44, # 49 p. 8853 - 8855

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Citation Number: 13

Abstract

Recently, a number of studies have attempted to develop a highly stereoselective method for synthesizing trisubstituted alkenes. 1., 2., 3. and 4. Although one such method, the stereoselective Horner–Wadsworth–Emmons (HWE) reaction of aldehydes, has been well established, 5., 6. and 7. moderate reactivity and selectivity are generally observed in the HWE reactions with ketones. 8. and 9. We have previously reported a versatile method for the stereoselective ...