N-Activated β-lactams as versatile reagents for acyl carrier protein labeling

…, JW Amoroso, LS Borketey, NA Schnarr

Index: Prasad, Gitanjeli; Amoroso, Jon W.; Borketey, Lawrence S.; Schnarr, Nathan A. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 10 p. 1992 - 2002

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Abstract

Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. Their primary function is to shuttle intermediates between active sites via a covalently bound phosphopantetheine arm. Small molecules capable of acylating this prosthetic group will provide a simple and reversible means of introducing novel functionality onto carrier protein domains. A series of N-activated β-lactams are prepared to examine site-specific acylation ...