Biologically relevant O, S-donor compounds. Synthesis, molybdenum complexation and xanthine oxidase inhibition

S Chaves, M Gil, S Canário, R Jelic, MJ Romao…

Index: Chaves, Silvia; Gil, Marco; Canario, Sonia; Jelic, Ratomir; Romao, Maria Joao; Trincao, Jose; Herdtweck, Eberhardt; Sousa, Joana; Diniz, Carmen; Fresco, Paula; Santos, M. Amelia Dalton Transactions, 2008 , # 13 p. 1773 - 1782

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Citation Number: 2

Abstract

Two O, S-donor ligands, hydroxythiopyrone and hydroxythiopyridinone derivatives, were developed and studied, as well as the corresponding O, O-derivatives, with a view to their potential pharmacological applications as xanthine oxidase (XO) inhibitors. The biological assays revealed that the O, S-ligands present high inhibitory activity towards XO (nanomolar order, close to that of the pharmaceutical drug allopurinol), in contrast to the ...