Chelator fragment libraries for targeting metalloproteinases

…, MT Miller, LH Chen, M Pellecchia, SM Cohen

Index: Agrawal, Arpita; Johnson, Sherida L.; Jacobsen, Jennifer A.; Miller, Melissa T.; Chen, Li-Hsing; Pellecchia, Maurizio; Cohen, Seth M. ChemMedChem, 2010 , vol. 5, # 2 p. 195 - 199

Full Text: HTML

Citation Number: 26

Abstract

Fragment-based lead design (FBLD), sometimes referred to as fragment-based drug discovery (FBDD), is an increasingly important strategy for the discovery of biologically active compounds.[1] FBLD generally uses libraries consisting of modest collections (100– 1000 compounds) of small molecular fragments (MW< 300 amu) that are screened against targets of interest.[2] Although such fragments do not bind as tightly (Kd values in the ...