Discovery of novel tetrahydro-pyrazolo [4, 3-c] pyridines for the treatment of neuropathic pain: Synthesis and neuropharmacology

…, M Sharma, G Samala, M Gangadhar, S Karthick…

Index: Yogeeswari, Perumal; Sharma, Monika; Samala, Ganesh; Gangadhar, Matharasala; Karthick, Srirama; Mallipeddi, Saketh; Semwal, Arvind; Sriram, Dharmarajan European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 211 - 220

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Citation Number: 6

Abstract

Abstract We disclose the discovery of a novel series of tetrahydropyrido-pyrazoles that are potent inhibitors of tumour necrosis factor-alpha (TNF-α), nitric oxide and cannabinoid receptor subtype 1 (CB 1). We report herein the synthesis and neuropharmacological screening results of the titled compounds in two acute pain and two neuropathic pain models in rodents. Particularly the analogue N-(4-bromophenyl)-3-tert-butyl-5-ethyl-4, 5, 6 ...