Chemistry of Pyrazine and Its Derivatives. III. The Synthesis of Carbinols by the Participation of Methylpyrazine in Aldol-type Condensations1

JD Behun, R Levine

Index: Behun; Levine Journal of the American Chemical Society, 1959 , vol. 81, p. 5666,5668

Full Text: HTML

Citation Number: 9

Abstract

Several aldehydes and ketones have been condensed with pyrazylmethylsodium to give the corresponding pyrazylmethylcarbinols, PzCHsC (OH) RR1, in fair to excellent yields. Diphenylpyrazylmethylcarbinol was reductively cleaved with ethanolic potassium hydroxide to give methylpyrazine and benzhydrol while its reaction with potassium hydroxide in t-butyl alcohol gave methylpyrazine and benzophenone. Benzophenone was also reduced to ...