Simplified analogues of immucillin-G retain potent human purine nucleoside phosphorylase inhibitory activity

T Semeraro, A Lossani, M Botta, C Ghiron…

Index: Slaitas; Yeheskiely Nucleosides, Nucleotides and Nucleic Acids, 2001 , vol. 20, # 4-7 p. 1377 - 1379

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Citation Number: 20

Abstract

... Purine nucleoside phosphorylase (PNP, EC 2.4.2.1) is an enzyme involved in the recycling of nucleosides and deoxynucleosides in cellular remodeling. ... 4 Accordingly, several base, nucleoside, and nucleotide analogues have been synthesized and tested as PNP inhibitors ...