Synthesis of antioxidative and anti-inflammatory drugs glucoconjugates

RK Uhrig, MA Picard, K Beyreuther, M Wiessler

Index: Uhrig, Rainer K.; Picard, Martin A.; Beyreuther, Konrad; Wiessler, Manfred Carbohydrate Research, 2000 , vol. 325, # 1 p. 72 - 80

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Citation Number: 60

Abstract

Glucoconjugates of (±)-ibuprofen,(±)-α-tocopherol (vitamin E), gentisic acid, gallic acid, 2, 6- bis (tert-butyl)-4-thiophenol, and N-acetyl-l-cysteine were prepared with the objective of increasing the bioavailability of such antioxidant and anti-inflammatory drugs. The O- glucosides were synthesized using benzylated α-d-glucopyranosyl trichloracetimidate as glycosyl donor. For the synthesis of the S-glucosides, the glycosyl donor 1, 2, 3, 4, 6-penta ...