Iron-catalyzed direct amination of azoles using formamides or amines as nitrogen sources in air

J Wang, JT Hou, J Wen, J Zhang, XQ Yu

Index: Wang, Jian; Hou, Ji-Ting; Wen, Jun; Zhang, Ji; Yu, Xiao-Qi Chemical Communications, 2011 , vol. 47, # 12 p. 3652 - 3654

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Abstract

Amino-substituted azoles are important scaffolds in medicinal chemistry. 9 Among the various approaches to these structures, direct C–H amination has been focused on for its atom economy. Inspiring progress regarding this synthetic method has occurred in past decade. 10 However, these methods always need high temperatures, a large amount of metal salts, additional oxidants, or a nitrogen atmosphere. Thus, we hoped to find a novel, mild and atom- ...