Synthesis, physicochemical and anticonvulsant properties of new N-[(4-arylpiperazin-1-yl) alkyl]-3-phenyl-and 3-(3-methyl-phenyl)-pyrrolidine-2, 5-diones

…, I Chlebek, J Pichor, M Kopytko, K Kaminski

Index: Obniska, Jolanta; Chlebek, Iwona; Pichor, Joanna; Kopytko, Maciej; Kaminski, Krzysztof Acta Poloniae Pharmaceutica - Drug Research, 2009 , vol. 66, # 6 p. 639 - 647

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Citation Number: 6

Abstract

Abstract: The series of N-[(4-arylpiperazin-1-yl)-alkyl]-3-phenyl-and 3-(3-methylphenyl)- pyrrolidine-2, 5-diones [VIII-XXV] were synthesized and evaluated for anticonvulsant and neurotoxic properties. Initial anticonvulsant screening was performed in mice, using intraperitoneal (ip) maximal electroshock-induced seizures (MES) and subcutaneous pentylenetetrazole-induced (scPTZ) seizure threshold tests. The neurotoxicity was ...

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