Automated Generation and Reactions of 3??Hydroxymethylindoles in Continuous??Flow Microreactors

T Tricotet, DF O'Shea

Index: Tricotet, Thomas; O'Shea, Donal F. Chemistry - A European Journal, 2010 , vol. 16, # 22 p. 6678 - 6686

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Citation Number: 29

Abstract

Abstract An automated sequential approach for the generation and reactions of 3- hydroxymethylindoles in continuous-flow microreactors is described. Consecutive halogen– magnesium exchanges of four 3-iodoindoles followed by addition to three aldehydes provided twelve 3-hydroxymethylindoles in a multi-microreactor setup. The synthetic flow strategy could be coupled with an in line continuous liquid–liquid extraction workup ...