Phosphonyltriethylammonium salts: novel reactive species for the synthesis of phosphonate esters and phosphonamides

…, W Moore, PA Sprengeler, J Witherington…

Index: Hirschmann, Ralph; Yager, Kraig M.; Taylor, Carol M.; Moore, William; Sprengeler, Paul A.; Witherington, Jason; Phillips, Barton W.; Smith III, Amos B. Journal of the American Chemical Society, 1995 , vol. 117, # 23 p. 6370 - 6371

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Citation Number: 28

Abstract

Phosphonate esters and amides find great utility as stable mimetics of tetrahedral transition states. Transition state analogs incorporating these functionalities have been exploited inter alia as enzyme inhibitors' and as haptens for catalytic antibody research,* including the recently reported formation of dipeptide~.~ Phosphonate esters and phosphonamides are generally prepared by the reaction of phosphonochloridates or phosphonodi~ hloridates~ ...