Tryptamine-derived alkaloids from Annonaceae exerting neurotrophin-like properties on primary dopaminergic neurons

F Schmidt, G Le Douaron, P Champy, M Amar…

Index: Schmidt, Fanny; Douaron, Gael Le; Champy, Pierre; Amar, Majid; Seon-Meniel, Blandine; Raisman-Vozari, Rita; Figadere, Bruno Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 14 p. 5103 - 5113

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Citation Number: 7

Abstract

N-fatty acyl tryptamines constitute a scarce group of natural compounds mainly encountered in Annonaceous plants. No biological activity was reported so far for these rare molecules. This study investigated the neurotrophic properties of these natural tryptaminic derivatives on dopaminergic (DA) neurons in primary mesencephalic cultures. A structure–activity relationships study led us to precise the role of a nitrogen atom into the aliphatic chain ...