The synthesis of substituted 2??aminothiazoles

Y Lin, CM Seifert, SM Kang, JP Dusza…

Index: Lin Yang-i; Seifert; Kang; et al. Journal of Heterocyclic Chemistry, 1979 , vol. 16, # 7 p. 1377 - 1383

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Citation Number: 18

Abstract

Abstract The preparation of 4-and 5-acyl-and aroyl-2-substituted aminothiazoles is described. The condensation of thioureas with acyl halides leading to 4, 5-disubstituted-2- aminothiazoles and 7-(4H) benzothiazolones is discussed. A discussion of the isolation of various intermediates and the mechanistic pathway is also included. A number of 2-anilino or 2-benzyl-4-or 5-aroylthiazoles possessed moderate oral antitubercolosis activity (2).