A Click procedure with heterogeneous copper to tether technetium-99m chelating agents and rhenium complexes. Evaluation of the chelating properties and …

…, V Moreau, D Lesur, M Artigau, C Picard, C Galaup…

Index: Benoist, Eric; Coulais, Yvon; Almant, Mehdi; Kovensky, Jose; Moreau, Vincent; Lesur, David; Artigau, Marine; Picard, Claude; Galaup, Chantal; Gouin, Sebastien G. Carbohydrate Research, 2011 , vol. 346, # 1 p. 26 - 34

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Citation Number: 27

Abstract

An efficient protocol was developed to tether chelating agents and rhenium complexes onto a glucoside scaffold with a heterogeneous copper catalyst via click chemistry. The supported catalyst avoids the formation of unwanted copper complexes during the cyclisation step. The possibility to graft a pre-chelated M (CO) 3 core by click chemistry onto a biomolecule was highlighted for the first time. 99mTc (CO) 3-glucoconjugates displayed excellent in vitro ...