N-substituted derivatives of 6, 11-dihydrodibenzo [b, e] thiepin-11-amine and related compounds; Synthesis and pharmacological screening

V Valenta, H Hulinská, J Holubek…

Index: Valenta, Vladimir; Hulinska, Hana; Holubek, Jiri; Dlabac, Antonin; Metys, Jan; et al. Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 860 - 869

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Citation Number: 3

Abstract

Abstract Reactions of N-(6, 11-dihydrodibenzo [b, e] thiepin-11-yl) chloroacetamide (II) with dimethylamine, morpholine, and 2-(1-piperazinyl) ethanol afforded the amino amides III-V. Substitution reactions of 11-chloro-6, 11-dihydrodibenzo [b, e] thiepin with ethylenediamine and N, N-dimethylethylenediamine gave the diamines VI and VII. 6, 11-Dihydrodibenzo [b, e] thiepin-11-amine (I) was treated with ethyl chloroacetate and ethyl 2-bromopropionate to ...

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