Graphite catalyzed solvent free synthesis of dihydropyrimidin-2 (1H)-ones/thiones and their antidiabetic activity

KL Dhumaskar, SN Meena, SC Ghadi…

Index: Dhumaskar, Kashinath L.; Meena, Surya Nandan; Ghadi, Sanjeev C.; Tilve, Santosh G. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 13 p. 2897 - 2899

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Citation Number: 11

Abstract

Abstract A solvent free three component condensation reaction between an aldehyde, ethyl acetoacetate and urea catalyzed by graphite, a green catalyst is described for the synthesis of dihydropyrimidin-2 (1H)-ones. This protocol is scalable and the catalyst is reusable. This method is also applied for the synthesis of dihydropyrimidin-2 (1H)-thiones. α-Amylase, a key enzyme in carbohydrate metabolism is generally targeted for management of type 2 ...