Non-nucleoside inhibitors of the measles virus RNA-dependent RNA polymerase complex activity: synthesis and in vitro evaluation

A Sun, N Chandrakumar, JJ Yoon, RK Plemper…

Index: Sun, Aiming; Chandrakumar, Nizal; Yoon, Jeong-Joong; Plemper, Richard K.; Snyder, James P. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 18 p. 5199 - 5203

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Citation Number: 27

Abstract

High-throughput screening has identified 1-methyl-3-(trifluoromethyl)-N-[4- (pyrrolidinylsulfonyl) phenyl]-1H-pyrazole-5-carboxamide 16677 as a novel and potent (IC50= 35–145nM) inhibitor against multiple primary isolates of diverse measles virus (MV) genotypes currently circulating worldwide. The synthesis of 16677 and several analogs together with effects on MV replication is described. The most potent analog displays ...