A novel oxidative decarboxylation—synthesis of 2-amino-1, 2-dihydroisoquinoline-3 (4H)-one and its amide derivatives from tetrahydroisoquinoline-3-carboxylic acid

…, M Umamaheswari, PS Mohan, S Rajagopal

Index: Gopalan; Umamaheswari, Mani; Mohan; Rajagopal, Sridharan Tetrahedron Letters, 2011 , vol. 52, # 42 p. 5441 - 5443

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Abstract

We are actively engaged in discovery of anti-inflammatory drugs. It is reported that 2-amino-1,2-dihydroisoquinoline-3(4H)-one and its amide derivatives have good anti-inflammatory properties and they inhibit metallo aminopeptidase. and In the literature and the title compounds 4 or 5 have been synthesised from homophthalic acid in five steps. N-phenylsydnone has been reported to give phenylhydrazine on treatment with HCl. 2 and 3 A survey of literature ...