2 (1H)-Quinolinones with cardiac stimulant activity. 3. Synthesis and biological properties of 6-imidazol-1-yl derivatives

…, SF Campbell, DS Morris, DA Roberts…

Index: Bell, Andrew S.; Campbell, Simon F.; Morris, David S.; Roberts, David A.; Stefaniak, Mark H. Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1552 - 1558

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Citation Number: 15

Abstract

CH3 velopment, 4* and phase I1 evaluation in congestive heart failure patients is in progress. This compound was some 5 times more potent than milrinone as an inotropic agent and also displayed a more prolonged duration of action after oral administration to conscious dog^.^,^ In order to extend these observations, a wider range of substituents has been introduced into the imidazolyl ring system in 1,596 and SARs for inotropic activity ...