Metal catalyzed multicomponent syntheses of secondary propargylamides and oxazoles from silylimines, acid chlorides, and alkynes

DA Black, BA Arndtsen

Index: Black, Daniel A.; Arndtsen, Bruce A. Tetrahedron, 2005 , vol. 61, # 48 p. 11317 - 11321

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Citation Number: 32

Abstract

Copper (I) and zinc (II) catalyzed routes to construct secondary propargylamides in one-pot procedures from aldehydes, LiN (TMS) 2, acid chlorides, and alkynes are described. This reaction has been subsequently used to provide a one-pot synthesis of oxazoles from four simple building blocks.