M 4 agonists/5HT 7 antagonists with potential as antischizophrenic drugs: Serominic compounds

…, H Yasumatsu, A McVie, LC Young, C McCraw…

Index: Suckling, Colin J.; Murphy, John A.; Khalaf, Abedawn I.; Zhou, Sheng-ze; Lizos, Dimitris E.; van Nhien, Albert Nguyen; Yasumatsu, Hiroshi; McVie, Allan; Young, Louise C.; McCraw, Corinna; Waterman, Peter G.; Morris, Brian J.; Pratt, Judith A.; Harvey, Alan L. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 9 p. 2649 - 2655

Full Text: HTML

Citation Number: 19

Abstract

Chronic low-dose treatment of rats with the psychomimetic drug, phencyclidine, induces regionally specific metabolic and neurochemical changes in the CNS that mirror those observed in the brains of schizophrenic patients. Recent evidence suggests that drugs targeting serotoninergic and muscarinic receptors, and in particular 5-HT7 antagonists and M4 agonists, exert beneficial effects in this model of schizophrenia. Compounds that ...

Rhodium catalyzed hydrogenation of quinolines and isoquinolines under water-gas shift conditions.

[Murahashi; Imada; Hirai Bulletin of the Chemical Society of Japan, 1989 , vol. 62, # 9 p. 2968 - 2976]

Hydrogenation of anthracene and nitrogen heterocycles catalyzed by iron pentacarbonyl under water-gas shift conditions

[Lynch, Thomas J.; Banah, Mahmoud; Kaesz, Herbert D.; Porter, Clifford R. Journal of Organic Chemistry, 1984 , vol. 49, # 7 p. 1266 - 1270]

N-formylation of amines by methanol activation

[Ortega, Nuria; Richter, Christian; Glorius, Frank Organic Letters, 2013 , vol. 15, # 7 p. 1776 - 1779]