Synlett

A Novel Protocol for Construction of Indolylmethyl Group at Aldehydes or Ketones

H Tokuyama, M Watanabe, Y Hayashi, T Kurokawa…

Index: Tokuyama; Watanabe; Hayashi; Kurokawa; Peng; Fukuyama Synlett, 2001 , # 9 p. 1403 - 1406

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Citation Number: 22

Abstract

Abstract: A new method for introduction of indolylmethyl group to aldehydes or ketones using diethyl (o-isocyanophenylmethyl) phosphonate through Horner-Wadsworth-Emmons condensation, thiolmediated radical cyclization, and the subsequent desulfurization is described. The Horner-Wadsworth-Emmons reagent was prepared from 2- nitrobenzaldehyde in a concise three-step sequence. Key words: 3-substituted indoles, ...

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