Nucleosides. 139. Synthesis and anticytomegalovirus and antiherpes simplex virus activity of 5'-modified analogs of 2'-fluoroarabinosylpyrimidine nucleosides

…, J Matulic-Adamic, RW Price, RF Schinazi…

Index: Harada, Kazuho; Matulic-Adamic, Jasenka; Price, Richard W.; Schinazi, Raymond F.; Watanabe, Kyoichi A.; Fox, Jack J. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 226 - 229

Full Text: HTML

Citation Number: 20

Abstract

In order to determine if modification of the 5'-position reduces or abolishes the antiviral activity of 2 '-fluoro-5-iodo-ara-C (FIAC), 2'-fluoro-5-iodo-ara-U (FIAU), or 2'-fluoro-5-methyl- ara-U (FMAU) against human cytomegalovirus (HCMV) and herpes simplex virus (HSV), the 5'-deoxy, 5'-mercapto, and 5'-amino analogues of these nucleosides were prepared. 5'- Deoxy-FIAC and 5'-deoxy-FIAU were prepared by catalytic hydrogenation of 5'-iodo-FIAC ...