Amino Acids

N-substituted aminomethanephosphonic and aminomethane-P-methylphosphinic acids as inhibitors of ureases

…, A Grabowiecka, A Białas, P Kosikowska, P Kafarski

Index: Berlicki, Lukasz; Bochno, Marta; Grabowiecka, Agnieszka; Bialas, Arkadiusz; Kosikowska, Paulina; Kafarski, Pawel Amino Acids, 2012 , vol. 42, # 5 p. 1937 - 1945

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Citation Number: 19

Abstract

Abstract Small unextended molecules based on the diamidophosphate structure with a covalent carbon-to-phosphorus bond to improve hydrolytic stability were developed as a novel group of inhibitors to control microbial urea decomposition. Applying a structure-based inhibitor design approach using available crystal structures of bacterial urease, N- substituted derivatives of aminomethylphosphonic and P-methyl-aminomethylphosphinic ...