Design, synthesis and biological evaluation of non-natural modulators of quorum sensing in Pseudomonas aeruginosa

JT Hodgkinson, WRJD Galloway, M Wright…

Index: Hodgkinson, James T.; Galloway, Warren R. J. D.; Wright, Megan; Mati, Ioulia K.; Nicholson, Rebecca L.; Welch, Martin; Spring, David R. Organic and Biomolecular Chemistry, 2012 , vol. 10, # 30 p. 6032 - 6044

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Citation Number: 26

Abstract

Many species of bacteria employ a mechanism of intercellular communication known as quorum sensing which is mediated by small diffusible signalling molecules termed autoinducers. The most common class of autoinducer used by Gram-negative bacteria are N- acylated-L-homoserine lactones (AHLs). Pseudomonas aeruginosa is a clinically important bacterium which is known to use AHL-mediated quorum sensing systems to regulate a ...