Crystal structures and pharmacologic activities of 1, 4-dihydropyridine calcium channel antagonists of the isobutyl methyl 2, 6-dimethyl-4-(substituted phenyl)-1, 4- …

…, E Luchowski, A Rutledge, DJ Triggle

Index: Fossheim, R.; Joslyn, A.; Solo, A. J.; Luchowski, E.; Rutledge, A.; Triggle, D. J. Journal of Medicinal Chemistry, 1988 , vol. 31, # 2 p. 301 - 305

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Citation Number: 71

Abstract

2-N02, 3-N02, 3-CN, 3-Me0, 4-F, 2-CF3, 3-CF3, and 4-C1) related to and including nisoldipine (X= 2-N02) has been synthesized, their solid-state structures determined by X- ray analysis (X= H, 2-N02, 3-N02, 3-CN, 3-Me0, and 4-F), and their pharmacologic activities determined, as the racemic compounds, against [3H] nitrendipine binding and K+- depolarization-induced tension responses in intestinal smooth muscle as measures of ...