Derivatives of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl) acetamide

BM Nilsson, B Ringdahl, U Hacksell

Index: Nilsson, Bjoern M.; Ringdahl, Bjoern; Hacksell, Uli Journal of Medicinal Chemistry, 1988 , vol. 31, # 3 p. 577 - 582

Full Text: HTML

Citation Number: 26

Abstract

A series of tertiary and quaternary analogues (acyclic imides, sulfonimides, N-acetyl sulfonamides, and trifluoroacetamides) of the selective partial muscarinic agonist N-methyl- N-(1-methyl-4-pyrrolidino-2-butyny1) acetamide (BM 5, 35) was synthesized. The compounds were found to be muscarinic agonists, partial agonists, or antagonists in the isolated guinea pig ileum. Replacement of the acetyl group or the N-methyl group of 35 ...