Design, synthesis, and antibacterial properties of dual-ligand inhibitors of acetyl-CoA carboxylase

MA Silvers, GT Robertson, CM Taylor…

Index: Midgley, Gary; Thomas, C. Barry Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1987 , p. 1103 - 1108

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Citation Number: 5

Abstract

... of andrimid is 6.8.(25) We prepared anhydride 15 (Scheme 3) from commercially available (4S)-methyl-succinic acid according to Midgley and Thomas(26) and ... The benzylic C–O bond in 21 was cleaved by hydrogenolysis to afford the hydroxylamine that was treated with 2 ...