Cytotoxic potential of novel 6, 7-dimethoxyquinazolines

…, BS Chouhan, PP Naik, R Giridhar, A Garofalo…

Index: Yadav, Mange R.; Grande, Fedora; Chouhan, Bishram S.; Naik, Prashant P.; Giridhar, Rajani; Garofalo, Antonio; Neamati, Nouri European Journal of Medicinal Chemistry, 2012 , vol. 48, p. 231 - 243

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Citation Number: 16

Abstract

Herein, we report the synthesis and cytotoxicity of a series of substituted 6, 7- dimethoxyquinazoline derivatives. The cytotoxic activity of all synthesized compounds has been evaluated against HCT116p53+/+ and HCT116p53−/− colon cancer cells and a HEY ovarian cancer cell line naturally resistant to cisplatin. Nine of the tested compounds showed significant cytotoxicity in all cell lines at 10μM. The most promising derivative (7c) showed ...